Shaun M. Eack

« All Research Faculty

Current Funded Research

R01 MH106450 Eack (PI)   06/01/2015-03/31/2020

NIH/NIMH      $3,242,082

Cognitive Enhancement Therapy for Adult Autism Spectrum DisorderThe purpose of this project is to conduct the first adequately-powered randomized-controlled trial of cognitive rehabilitation in adults with autism spectrum disorder.  Adults with autism spectrum disorder will be randomized to an 18-month controlled trial of Cognitive Enhancement Therapy (CET) or Enriched Supportive Therapy (EST).  Specific aims are to evaluate the comparative effectiveness of CET versus EST for improving cognitive and behavioral outcomes, to examine the impact of CET on underlying neural mechanisms of cognitive enhancement, and to identify personal and neurobiological moderators of treatment response.

R01 MH-92440 Eack (PI with Keshavan) 06/01/2012 - 05/31/2018 (in NCE)

NIH/NIMH      $3,169,437

Brain Imaging, Cognitive Enhancement and Early SchizophreniaThe purpose of this grant is to examine the effects of a novel cognitive rehabilitation program, Cognitive Enhancement Therapy (CET), on the brain in individuals with early course schizophrenia.  Specifically, an 18-month clinical trial of CET will be conducted and use integrated neuroimaging techniques to repeatedly assess brain function, structure, and connectivity during the course of CET treatment, as well as the predictive contribution of brain reserves to treatment response.  Further, a 1-year post-treatment durability study will be conducted to examine the degree to which neurobiologic, cognitive, and functional effects can be sustained post-treatment in early course schizophrenia patients.

Role: Co-PI

Current Funding Sources

National Institute of Mental Health,

Past Funding

Autism Research Institute, Department of Defense, National Institute of Mental Health, National Institute on Drug Abuse, Staunton Farm Foundation,

Review Grants

Department of Defense, National Institute of Mental Health,

Research Methodology

Longitudinal Research, Meta- Research, Psychometrics/Scale Development, Quantitative, Secondary Data Analysis,

Data Collection

In-depth interviews, Quantitative Surveys,

Quantitative Analysis

Correlation & Association, Generalized Linear Mixed Models, HLM/mixed-effects models (linear), Independent-sample t test, Logistic Regression, Mixed Effects Logistic Regression, Multivariate Multiple Regression, One-way ANOVA, One-way MANOVA, Paired- sample t test, Single-sample t test, Time Series Analysis, Two independent proportions,

Analytic Programs

Mplus, R, SPSS,

Familiarity with data sizes


Research Content

Adults, Case Management, Employment, Race & Ethnicity, Cognitive Enhancement Therapy, Neurocognitive Disorders, Neurodevelopmental Disorders, Schizophrenia/Other Psychotic Disorders, Supportive Therapy,


American Journal of Psychiatry, JAMA Psychiatry, Psychological Medicine, Schizophrenia Bulletin, Social Work,